儿童期垂体瘤

儿童期垂体瘤比较少见，不同国家报道的发病率没有明显差别，占所有儿童期颅内肿瘤的1.1%左右。小儿垂体瘤患者通常在儿童时期即有症状，但大多数手术是在青少年时做的。在儿童期，促肾上腺皮质激素细胞腺瘤和催乳素腺瘤是最常见的类型（在青春期前以促肾上腺皮质激素细胞腺瘤为多见，而在青春期或青春期以后则以催乳素腺瘤为多见），非功能性腺瘤非常少见。相对于成年人，促甲状腺素细胞腺瘤在儿童中非常少见。

组织学检查发现大部分肿瘤具有多种激素免疫阳性。有报道10%的多激素腺瘤在儿童期或青少年期进行手术。有人认为儿童期垂体瘤比成年人垂体瘤更具局部浸润性或攻击性，但也有人否认这种观点。

（刘相名　惠国桢）

参考文献

[1] Cavagnini F, Pecori Giraldi F. Epidemiology and follow-up of Cushing's disease. Ann Endocrinol (Paris), 2001,62(2):168-172.

[2] Davis JR, Farrell WE, Clayton RN. Pituitary tumours. Reproduction, 2001,121(3): 363-371.

[3] Clayton RN. Sporadic pituitary tumours: from epidemiology to use of databases. Baillieres Best Pract Res Clin Endocrinol Metab, 1999,13(3):451-460.

[4] Monson JP. The epidemiology of endocrine tumours. Endocr Relat Cancer, 2000, 7(1):29-36.

[5] Nilsson B, Gustavasson-Kadaka, Bengtsson BA, et al.Pituitary adenomas in Sweden between 1958 and 1991: incidence, survival, and mortality. J Clin Endocrinol Metab, 2000,85(4):1420-1425.

[6] Lafferty AR, Chrousos GP. Pituitary tumors in children and adolescents.J Clin Endocrinol Metab, 1999,84(12):4317-4323.

[7] Turner HE, Adams CB, Wass JA. Pituitary tumours in the elderly: a 20 year experience. Eur J Endocrinol, 1999,140(5):383-389.

[8] Sklar CA. Childhood brain tumors. J Pediatr Endocrinol Metab, 2002,15 Suppl 2:669-673.

[9] Duntas LH. Prolactinomas in children and adolescents-consequences in adult life. J Pediatr Endocrinol Metab, 2001,14 Suppl 5:1227-1232.

[10] Popovic V. Damjonavic S, Micic D, et al. Increased incidence of neoplasia in patients with pituitary adenomas. The Pituitary Study Group. Clin Endocrinol, 1998, 49(4):441-445.

[11] Artese R, D’Osvalda DH, Molocznik I, et al. Pituitary tumors in adolescent patients. Neurol Res, 1998,20(5):415-417.

[12] Faglia G. Epidemiology and pathogenesis of pituitary adenomas. Acta Endocrinol, 1993,129(Suppl):1-5.

[13] Radhakrishnan K, Mokri B, Parisi JE, et al. The trends in incidence if primary brain tumors in the population of Rochester, Minnesota. Ann Neurol, 1995,37:67-73.

[14] Kuratsu J, Ushio Y. Epidemiological study of primary intracranial tumors: a regional survyin Kumamoto Prefecture in the southern part of Japan. J Neurosurg, 1996,84: 946-950.

[15] Christy NP. Diagnosis and treatment of pituitary tumors. In: Beeson PB, McDermott W, eds. Textbook of Medicine, 14th ed. WB Saunders, Philadelphia, 1975,pp,1687-1689.

[16] Ambrosi B, Faglia G. Epidemiology of pituitary tumors. In: Faglia G, Beck-Peccoz P, Ambrosi B, Travaglini P, Spada A, eds. Pituitary Adenomas: New Trends in Basic and Clinical Research. Elsevier Science Publishers, Amsterdam, The Netherlands, 1991:159-168.

[17] Batrinos ML, Panitsa FC, Tsiganou E, et al. Incidence and characteristics of microprolactinomas(3-5 mm) in 4199 women assayed for prolactin.Horm Matab Res, 1992,24:384-391.

[18] Etxabe J, Vazque JA. Morbidity and mortality in Cushing’s disease: an epidemiological approach. Clin Endocrinol, 1994,40:479-484.

[19] Helseth A. The incidence of primary central nervous system neoplasms before and after computerized tomography availability. J Neurosurg, 1995,83:999-1003.

[20] Terada T, Kovacs K, Stefaneanu L, et al. Incidence, patholoty, and recurrence of pituitary adenomas: study of 647 unselected surgical cases. Endocrinol Pathol, 1995,6: 301-310.

[21] Uei Y, Kanzaki M, Yabana T. Incidental adenomas of the human pituitary gland. Endocr Pathol, 1994,5:90-99.

[22] Partington MD, Davis DH, Laws ER Jr, et al. Pituitary adenomas in childhood and adolescence. J Neurosurg, 1994,80:209-216.